2024
Malla SB, Byrne RM, Lafarge M, Corry SM, Fisher NC, Tsantoulis P, Campbell AD, Lannagan TR, Najumudeen AK, Gilroy K, Amirkhah R, Maguire M, Mulholland E, Belnoue-Davis HL, Grassi E, Viviani M, Rogan E, Redmond K, Sakhnevych S, McCooey A, Bull C, Miller C, Bertotti A, Trusolino L, Loughrey M, Kerr E, Tejpar S, Maughan T, Lawler M, Leedham SJ, Koelzer VH, Sansom OJ, Dunne PD
Nature Genetics, 2024
Najumudeen AK*, Fey SK, Millett LM, Ford C, Gilroy K, Gunduz N, Ridgway RA, Anderson E. Strathdee D, Clark W, et al.
Nature Communications, 2024 (*corresponding author)
Fey SK, Najumudeen AK*, Ford C, Gilroy K, Upstill-Goddard R, Chang, DK, Clark W, Nixon C, Barry ST, Morton JP, et al.
KRAS loss of heterozygosity promotes MAPK-dependent pancreatic ductal adenocarcinoma and induces therapeutic sensitivity
BioRxiv, 2023, 2023.08.29.552598. 10.1101/2023.08.29.552598 (*corresponding author).
2023
Manoharan GB, Guzmán C, Najumudeen AK, Abankwa D
Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements
European Journal of Cell Biology, 151314
Voorde JV, Najumudeen AK, Steven RT, Nikula CJ, Dexter A, Zeiger LB, Elia EA, Nasif A, Gonzalez-Fernandez A, Murta T, Gillespie M, Ford CA, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Gilroy K, Gay DM, Burton A, et al., Sansom, OJ
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
Nature Metabolism, 2023
2022
Vasquez EG, Nasreddin N, Valbuena GN, Mulholland EJ, Belnoue-Davis HL, Eggington HR, Schenck RO, Wouters VM, Wirapati P, Gilroy K, Lannagan TRM, Flanagan DJ, Najumudeen AK, Omwenga S, McCorry AMB, Easton A, Koelzer VH, East JE, Morton D, Trusolino L, Maughan T, Campbell AD, Loughrey MB, Dunne PD, Tsantoulis P, Huels DJ, Tejpar S, Sansom OJ, Leedham SJ.
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
Cell Stem Cell, 2022
Holt AK, Najumudeen AK, Hoskin J, Legge DN, Mortensson E, Flanagan DJ, Jones N, Kollareddy M, Collard TJ, Timms P, Sansom OJ, Williams AC, and Vincent EE.
Aspirin Reprogrammes Colorectal Cancer Cell Metabolism and Sensitises to Glutaminase Inhibition
bioRxiv, 2022, 2022.08.24.505115. doi:10.1101/2022.08.24.505115.
Lilja J, Kaivola J, Conway JRW, Vuorio J, Parkkola H, Roivas P, Varila T, Jacquemet G, Peuhu E, Wang E, Pentikäinen U, Posada IMD, Hamidi H, Najumudeen AK, Sansom OJ, Barsukov IL, Abankwa D, Vattulainen I, Salmi M, and Ivaska J.
Targeting a Broad Spectrum of KRAS-Mutant Cancers by Hyperactivation-Induced Cell Death
bioRxiv, 2022, 2022.09.21.508660. doi:10.1101/2022.09.21.508660.
2021
Kiourtis C, Terradas-Terradas M, Gee LM, Hsieh YC, Nixon C, Clark C, Shaw R, Hanson PS, Sumpton D, Mackay G, May S, Müller M, Najumudeen AK, Campbell A, Barry ST, Morris CM, LeBeau FE, Sansom OJ, Kirschner K, Oakley F, Bird TG.
Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGF-β signalling pathway.
bioRxiv 1–28 (2021). doi:10.21203/RS.3.RS-1133747/V1.
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ.
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
Nature Genetics January 1, 2021
Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Nature May 6, 2021
Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JD, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ.
MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression
Cancer Discovery January 5, 2021
Pickering KA, Gilroy K, Cassidy JW, Fey SK, Najumudeen AK, Zeiger LB, Vincent DF, Gay DM, Johansson J, Fordham RP, Miller B, Clark W, Hedley A, Unal EB, Kiel C, McGhee E, Machesky LM, Nixon C, Johnsson AE, Bain M, Strathdee D, van Hoof SR, Medema JP, Anderson KI, Brachmann SM, Stucke VM, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell AD, Sansom OJ.
A RAC-GEF network critical for early intestinal tumourigenesis
Nature Communications January 14, 2021
Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium, van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ.
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Nature Communications August 6, 2021
Sharbeen G, McCarroll JA, Akerman A, Kopecky C, Youkhana J, Kokkinos J, Holst J, Boyer C, Erkan M, Goldstein D, Timpson P, Cox TR, Pereira BA, Chitty JL, Fey SK, Najumudeen AK, Campbell AD, Sansom OJ, Ignacio RMC, Naim S, Liu J, Russia N, Lee J, Chou A, Johns A, Gill AJ, Gonzales-Aloy E, Gebski V, Guan YF, Pajic M, Turner N, Apte MV, Davis TP, Morton JP, Haghighi KS, Kasparian J, McLean BJ, Setargew YF, Phillips PA; Australian Pancreatic Cancer Genome Initiative.
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition
Cancer Research January 1, 2021
Najumudeen AK, Köhnke M, Solman M, Alexandrov K, Abankwa D.
Cellular FRET-Biosensors to detect Membrane Targeting Inhibitors of N-Myristoylated Proteins
Plos ONE, 8(6): e66425.
Najumudeen AK, Jaiswal A, Lectez B, Oetken-Lindholm C, Guzmán C, Siljamäki E, Posada IM, Lacey E, Aittokallio T, Abankwa D.
Cancer stem cell drugs target K-ras signaling in a stemness context.
Oncogene March 14, 2016
Najumudeen AK.
Receptor Tyrosine Kinase Transmem- brane Domain Interactions: Potential Target for “Interceptor” Therapy
Science Signaling September 7, 2010