Vasquez EG, Nasreddin N, Valbuena GN, Mulholland EJ, Belnoue-Davis HL, Eggington HR, Schenck RO, Wouters VM, Wirapati P, Gilroy K, Lannagan TRM, Flanagan DJ, Najumudeen AK, Omwenga S, McCorry AMB, Easton A, Koelzer VH, East JE, Morton D, Trusolino L, Maughan T, Campbell AD, Loughrey MB, Dunne PD, Tsantoulis P, Huels DJ, Tejpar S, Sansom OJ, Leedham SJ.

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

Cell Stem Cell, 2022

Holt AK, Najumudeen AK, Hoskin J, Legge DN, Mortensson E, Flanagan DJ, Jones N, Kollareddy M, Collard TJ, Timms P, Sansom OJ, Williams AC, and Vincent EE.

Aspirin Reprogrammes Colorectal Cancer Cell Metabolism and Sensitises to Glutaminase Inhibition

bioRxiv, 2022, 2022.08.24.505115. doi:10.1101/2022.08.24.505115.

 

Lilja J, Kaivola J, Conway JRW, Vuorio J, Parkkola H, Roivas P, Varila T, Jacquemet G, Peuhu E, Wang E, Pentikäinen U, Posada IMD, Hamidi H, Najumudeen AK, Sansom OJ, Barsukov IL, Abankwa D, Vattulainen I, Salmi M, and Ivaska J.

Targeting a Broad Spectrum of KRAS-Mutant Cancers by Hyperactivation-Induced Cell Death

bioRxiv, 2022, 2022.09.21.508660. doi:10.1101/2022.09.21.508660.

 

Kiourtis C, Terradas-Terradas M, Gee LM, Hsieh YC, Nixon C, Clark C, Shaw R, Hanson PS, Sumpton D, Mackay G, May S, Müller M, Najumudeen AK, Campbell A, Barry ST, Morris CM, LeBeau FE, Sansom OJ, Kirschner K, Oakley F, Bird TG.

Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGF-β signalling pathway.

bioRxiv 1–28 (2021). doi:10.21203/RS.3.RS-1133747/V1.

Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium, Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ.

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Nature Genetics January 1, 2021

Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, Nasreddin N, Hodder MC, Ridgway RA, Minnee E, Sphyris N, Gilchrist E, Najumudeen AK, Romagnolo B, Perret C, Williams AC, Clevers H, Nummela P, Lähde M, Alitalo K, Hietakangas V, Hedley A, Clark W, Nixon C, Kirschner K, Jones EY, Ristimäki A, Leedham SJ, Fish PV, Vincent JP, Katajisto P, Sansom OJ.

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

Nature May 6, 2021

Knight JRP, Alexandrou C, Skalka GL, Vlahov N, Pennel K, Officer L, Teodosio A, Kanellos G, Gay DM, May-Wilson S, Smith EM, Najumudeen AK, Gilroy K, Ridgway RA, Flanagan DJ, Smith RCL, McDonald L, MacKay C, Cheasty A, McArthur K, Stanway E, Leach JD, Jackstadt R, Waldron JA, Campbell AD, Vlachogiannis G, Valeri N, Haigis KM, Sonenberg N, Proud CG, Jones NP, Swarbrick ME, McKinnon HJ, Faller WJ, Le Quesne J, Edwards J, Willis AE, Bushell M, Sansom OJ.

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

Cancer Discovery January 5, 2021

Pickering KA, Gilroy K, Cassidy JW, Fey SK, Najumudeen AK, Zeiger LB, Vincent DF, Gay DM, Johansson J, Fordham RP, Miller B, Clark W, Hedley A, Unal EB, Kiel C, McGhee E, Machesky LM, Nixon C, Johnsson AE, Bain M, Strathdee D, van Hoof SR, Medema JP, Anderson KI, Brachmann SM, Stucke VM, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell AD, Sansom OJ.

A RAC-GEF network critical for early intestinal tumourigenesis

Nature Communications January 14, 2021

Leach JDG, Vlahov N, Tsantoulis P, Ridgway RA, Flanagan DJ, Gilroy K, Sphyris N, Vázquez EG, Vincent DF, Faller WJ, Hodder MC, Raven A, Fey S, Najumudeen AK, Strathdee D, Nixon C, Hughes M, Clark W, Shaw R; S:CORT consortium, van Hooff SR, Huels DJ, Medema JP, Barry ST, Frame MC, Unciti-Broceta A, Leedham SJ, Inman GJ, Jackstadt R, Thompson BJ, Campbell AD, Tejpar S, Sansom OJ.

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Nature Communications August 6, 2021

Sharbeen G, McCarroll JA, Akerman A, Kopecky C, Youkhana J, Kokkinos J, Holst J, Boyer C, Erkan M, Goldstein D, Timpson P, Cox TR, Pereira BA, Chitty JL, Fey SK, Najumudeen AK, Campbell AD, Sansom OJ, Ignacio RMC, Naim S, Liu J, Russia N, Lee J, Chou A, Johns A, Gill AJ, Gonzales-Aloy E, Gebski V, Guan YF, Pajic M, Turner N, Apte MV, Davis TP, Morton JP, Haghighi KS, Kasparian J, McLean BJ, Setargew YF, Phillips PA; Australian Pancreatic Cancer Genome Initiative.

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition

Cancer Research January 1, 2021

Najumudeen AK, Köhnke M, Solman M, Alexandrov K, Abankwa D.

Cellular FRET-Biosensors to detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

Plos ONE, 8(6): e66425.

​

Najumudeen AK, Jaiswal A, Lectez B, Oetken-Lindholm C, Guzmán C, Siljamäki E, Posada IM, Lacey E, Aittokallio T, Abankwa D.

Cancer stem cell drugs target K-ras signaling in a stemness context.

Oncogene March 14, 2016

Najumudeen AK.

Receptor Tyrosine Kinase Transmem- brane Domain Interactions: Potential Target for “Interceptor” Therapy

Science Signaling September 7, 2010